Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy.
作者： Irina V. Guzhova , Maxim A. Shevtsov , Sergey V. Abkin , Katerina M. Pankratova , Boris A. Margulis
DOI: 10.3109/02656736.2013.807439
关键词:
摘要: AbstractPurpose: Heat shock protein 70 (HSPA family) is a multi-functional which protects individual cells from proteotoxic and the whole organism microbial, viral oncogenic pathogens. These diverse functions may depend upon ‘chaperone’ activity that allows Hsp70 to regulate mechanism of damaged recovery or utilisation inside cell be potent adjuvant, stimulating immune against variety tumour antigens. The aim this review present recent data on specific roles intracellular extracellular in cancerous tissue.Conclusion: presented paper show endogenous cancer different origins cytotoxic threats including therapeutics. In contrast, however, released stressed can serve as danger signal recruit responsible for generation innate adaptive responses cells.
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