Negative regulation of the Apaf-1 apoptosome by Hsp70
作者： Ayman Saleh , Srinivasa M. Srinivasula , Levent Balkir , Paul D. Robbins , Emad S. Alnemri
DOI: 10.1038/35019510
关键词:
摘要: Release of cytochrome c from mitochondria by apoptotic signals induces ATP/dATP-dependent formation the oligomeric Apaf-1-caspase-9 apoptosome. Here we show that documented anti-apoptotic effect principal heat-shock protein, Hsp70, is mediated through its direct association with caspase-recruitment domain (CARD) Apaf-1 and inhibition apoptosome formation. The interaction between Hsp70 prevents oligomerization procaspase-9. On basis these results, propose resistance to apoptosis exhibited stressed cells some tumours, which constitutively express high levels may be due in part modulation function Hsp70.
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