Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups and method of application thereof
作者： Kurt G. Hofer , Li-xi Yang
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摘要: A compound comprising and diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In preferred embodiment the has formula wherein comprises carbon having about 2-10 in chain, R 1 , 2 3 4 are H, T, T A′ chain 1-8 5 lower alkyl, halo, 6 halo nitro, provided that at least one of T. Intermediates for, pharmaceutical compositions containing, methods for making using such compounds to radiosensitize kill hypoxic tumor cells also
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