A two-phase model of plantar tissue: a step toward prediction of diabetic foot ulceration.

摘要: A new computational model, based on the thermodynamically constrained averaging theory, has been recently proposed to predict tumor initiation and proliferation. similar mathematical approach is here as an aid in diabetic ulcer prevention. The common aspects at continuum level are macroscopic balance equations governing flow of fluid phase, diffusion chemical species, tissue mechanics, some constitutive equations. soft plantar modeled a two-phase system: solid phase consisting cells their extracellular matrix, one (interstitial dissolved species). may become necrotic depending stress oxygen availability tissue. Actually, patients, peripheral vascular disease impacts necrosis; this considered model via introduction effective coefficient that governs transport nutrients within microvasculature. discretized space by finite element method time domain using θ-Wilson Method. While full developed paper, example limited simulation several gait cycles healthy foot.