A Critical Role of Toll-like Receptor 2 in Nerve Injury-induced Spinal Cord Glial Cell Activation and Pain Hypersensitivity

摘要: The activation of spinal cord glial cells has been implicated in the development neuropathic pain upon peripheral nerve injury. molecular mechanisms underlying cell activation, however, have not clearly elucidated. In this study, we found that damaged sensory neurons induce expression tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and inducible nitric-oxide synthase genes cells, which is pain. Studies using primary isolated from toll-like receptor 2 knock-out mice indicate activate via 2. addition, behavioral studies demonstrate required for induction mechanical allodynia thermal hyperalgesia due to axotomy. injury-induced microglia astrocyte reduced mice. Similarly, pro-inflammatory gene also These data contributes subsequent hypersensitivity.