TOTAL IgE, SPECIFIC IgE AND ASCARIS INFECTION AND THE EXPRESSION OF SKIN-TEST POSITIVITY AND ATOPIC DISEASES

摘要: Studies show rising rates of allergies and asthma in Africa, with increasing prevalence allergic diseases all communities, especially rural black African subjects. There is a complex interplay between environmental genetic factors that affect the manifestation Africa. The setting wonderful ‘natural experiment’ where populations have co-evolved parasites micro-organisms, possibly leading to pro-allergic potential, which has, however, been mitigated by continued exposure traditional environment downregulate potential. This situation leads differences presentation diagnosis allergy Africa from those First World settings. For example, urban migration may lead lack family history subjects, parasite infestation be an important factor dictating total IgE levels, also effect on reducing skin reactivity.