Associations between asthma and bronchial hyper-responsiveness with allergy and atopy phenotypes in urban black South African teenagers.
作者： C Motala , R Muloiwa , M E Levin
DOI: 10.7196/SAMJ.4670
关键词:
摘要: Objectives. To determine asthma and allergy phenotypes in unselected urban black teenagers to associate bronchial hyperresponsiveness (BHR) with asthma, other atopic diseases allergen sensitisation. Methods. This was a cross-sectional study of 211 highschool children Xhosa ethnicity. Modified ISAAC questionnaires regarding eczema rhinitis were administered. BHR assessed by methacholine challenge using hand-held nebulisers. Skinprick tests (SPTs) performed for 8 aeroallergens 4 food allergens. Results. Asthma reported 9%, 16% demonstrated BHR. Rhinitis 48% 19%. strongly associated whereas rhinitis. SPTs positive 34% subjects, 32%, allergens 5%. The most common sensitivities house dust mites (HDM) German cockroach. sensitivity any aeroallergen, cat, HDM, cockroach Bermuda grass. number With each level SPT positivity, there 40% increased prevalence 70% rate sensitisation subjects (72%) much higher than those without (28%); mite 69% 18% without. Conclusions. These are the highest rates documented an African setting widest difference between
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