Increasing time to treatment initiation for head and neck cancer: An analysis of the National Cancer Database

摘要: BACKGROUND The objective of this study was to identify trends and predictors the time treatment initiation (TTI) for patients with head neck squamous cell carcinoma (HNSCC). METHODS The National Cancer Database (NCDB) reviewed following cancer sites: oral tongue, oropharynx, larynx, hypopharynx. TTI defined as number days from diagnosis definitive measured according covariates. Significant differences in median across each covariate were using Kruskal-Wallis test, Spearman test used measure within For multivariate analysis, a zero-inflated, negative, binomial regression model estimate expected TTI, which expressed predicted days; Vuong TTI. RESULTS In total, 274,630 included. Between 1998 2011, all 26 days, it increased 19 30 (P < .0001). Treatment chemoradiation (CRT) (P < .0001), at academic facilities stage IV disease (P < .0001) associated TTI. significantly modality facility type over time. In addition, became more likely transition care between after On (33 days), transitioning (37 receipt CRT (39 days) longer TTI. CONCLUSIONS TTI is rising HNSCC. Those who have advanced-stage disease, receive CRT, are treated facilities, realized greatest increases 2015;121:1204–1213. © 2014 American Society.