Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma.

摘要: Background To investigate the association between diagnosis-to-treatment interval (DTI) and overall survival (OS) in patients with oral cavity squamous cell carcinoma (OSCC). Methods A total of 18,677 first primary OSCC identified Taiwanese Cancer Registry Database 2004 2010 were examined. The effect DTI on 5-year OS rates was investigated multivariate Cox regression analysis. After identification optimal cutoff for based rates, classified following 20-day groups: ≤20 days (57% study patients), 21–45 (34%), 46–90 (6%) and ≥91 (3%). In additional exploratory analyses, reclassified 30-day ≤30 (81% 31–60 (14%), 61–90 (2%) and (3%). Results Multivariate analyses (≤20 versus other subgroups), sex (female versus male), age (<65 versus ≥65 years), clinical stage (p-stage I versus p-stage II, III, IV) and treatment modality (initial surgery versus initial non-surgery) as independent prognostic factors OS. Compared a days, categories (hazard ratio [HR]: 1.28, P < 0.001), (HR: 1.25, P < 0.001) 1.07, P = 0.007) independently associated higher risk mortality. Similar results obtained groups. Conclusions DTI is patients. A longer than 30 or even 20 may potentially decrease survival.