Central visual fields for short wavelength sensitive pathways in glaucoma and ocular hypertension.

摘要: While conventional clinical visual acuity and kinetic fields may be essentially normal in ocular hypertension early stages of glaucoma, other foveal aspects vision (eg color, spatial temporal contrast sensitivity) quite abnormal. Specifically, a selective vulnerability the short wavelength sensitive (SWS) pathways these conditions has previously been noted. Here we studied central 33 primary open angle glaucoma (POAG) patients, 32 hypertensives (OHT), 24 age-matched controls using blue yellow test flashes on bright backgrounds. SWS cone MWS and/or LWS pathway sensitivities were measured at fovea 2.5 degrees, 5 10 degrees 15 eccentricities, either inferior (for OHT) or horizontal nasal retina POAG). As expected, all groups had sensitivity to flashes--detected by cones--in meridians. By comparison, for cones--the POAG OHT deficits, uniformly across field, about 6X 1.8X, respectively, compared normals. six 31 (19%) subjects localized glaucomatous field defects (greater than 0.4 log units) non-foveal retina, none 12 who also tested showed loss this meridian. Finally, while no four did show local with flashes.(ABSTRACT TRUNCATED AT 250 WORDS)