Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women.

摘要: This cross-sectional study shows that high numbers of postmenopausal women with acromegaly develop vertebral fractures in relation to the activity disease. In patients active acromegaly, occur even presence normal BMD, whereas controlled are always accompanied by a pathological BMD. Introduction: We studied frequency radiological cohort or acromegaly. Materials and Methods: Thirty-six acromegalic (15 21 disease) were evaluated for bone metabolism (serum 25-hydroxyvitamin D, PTH, bone-specific alkaline phosphatase {BSALP}, urinary deoxypyridinoline {Dpd}), quantitative morphometry. nonacromegalic women, matched age, selected among consulting Bone Center as control group BMD evaluation morphometry. Results: Vertebral shown 19 (52.8%) 11 controls (30.6%; χ2: 3.7; p = 0.06). Fractured older had higher serum IGF-1, Dpd, BSALP lower T score vitamin D values compared nonfractured patients. Moreover, fractured longer diagnosis period than women. The fracture rate was significantly (80% versus 33.3%; 7.6; 0.008). who (12 cases) IGF-1 (356 ng/ml; range: 212–950 120 84–217; −1.0 SD), osteopenia osteoporosis found only 33.3% 25.0% them, respectively. Conclusions: Furthermore, our that, BMD.