Passive immunization for immunocontraception: lessons learned from infectious diseases.

摘要: Development of vaccine for contraception is an exciting proposition that could provide a valuable alternative to the presently available methods birth control. Various targets such as gonadotropin releasing hormone (GnRH), follicle stimulating (FSH), leutinizing (LH), zona pellucida (ZP) antigens, sperm and human chorionic (hCG) are being explored immunocontraception. Besides specific concerns associated with each contraceptive vaccine, progress has been restricted by variability immune response after active immunization, attain maintain high antibody titers, time lag achieve reasonably good uncertainty regarding how long bioeffective antibodies will remain in circulation. It envisaged these may be taken care using preformed passive immunization approach. The therapies have tried found successful against various infectious diseases both animals well humans. Some become treatment modalities clinics. This manuscript review data polyclonal murine/humanized/human monoclonal antibodies, their efficacy, mode delivery, duration effects, limitations, if any. overall objective examine feasibility practicability approach