Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian–human immunodeficiency virus infection

摘要: Although maternal human immunodeficiency virus type 1 (HIV-1) transmission occurs during gestation, intrapartum and postpartum (by breast-feeding), 50-70% of all infected children seem to acquire HIV-1 shortly before or delivery. Epidemiological evidence indicates that mucosal exposure is an important aspect HIV transmission. A simian (SIV) macaque model has been developed mimics the can occur To develop immunoprophylaxis against transmission, we used SHIV-vpu+ (refs. 5,6), a chimeric simian-human encodes env gene HIV-IIIB. Several combinations monoclonal antibodies have identified neutralize completely in vitro through synergistic interaction. Here, treated four pregnant macaques with triple combination IgG1 F105, 2G12 2F5. All were protected intravenous challenge after The infants received birth challenged orally thereafter. We found no infection any infant 6 months follow-up. This demonstrates protect lentivirus neonates. conclude epitopes recognized by three are determinants for achieving substantial protection, thus providing rational basis AIDS vaccine development.