Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance.
作者： H. H. Loh , E. L. Way , R. A. Harris
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摘要: The analgesic effect of morphine was antagonized in mice by intracerebroventricular injection Ca++, Mg++ and Mn++ potentiated ethylene glycol tetraacetic acid but not altered Sr++, Ba++, Ni++, Hg++, Cd++ or ethylenediamine acid. antagonistic Ca++ pretreatment with pargyline 6-hydroxydopamine indicating that release catecholamines serotonin involved this action Ca++. Induction tolerance pellet implantation also did alter the effects naloxone were additive both nontolerant tolerant animals apparent affinity for its receptors, as estimated vivo pA2 determinations, However, ionophore X537A found to increase greatly narcotic antagonist a low dose although alone morphine. This indicates Ca"++ must penetrate cell membranes order reduce These findings indicate importance localization actions agonists antagonists.
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