Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients.

摘要: Although tumor-associated macrophages (TAMs) are essential for cancer progression, connections between different clinical outcomes and transcriptional networks have not been reported. We addressed this issue by analyzing global expression patterns of TAMs isolated from the ascites ovarian patients. patients can be stratified coexpression or principal component analysis into subgroups with specific biological features associated distinct outcomes. A hallmark subgroup is a high clinically unfavorable markers, including (i) high CD163 expression, surface receptor characteristic an anti-inflammatory activation state, (ii) increased PCOLCE2 indicative enhanced extracellular matrix organization, (iii) elevated levels IL-6 IL-10, linked to aggressiveness immune suppression. In contrast, B characterized upregulation genes defense mechanisms interferon (IFN) signaling. Intriguingly, published data 1763 revealed strong association signature longer overall survival. Consistent these results, IFNγ was able abrogate suppressive effect on inducibility IL12B IL-12 secretion, key determinant cytotoxic response. The survival presence that low protumorigenic immunosuppressive markers observed IFNγ-mediated restoration in provides possible explanation signaling-associated favorable outcome.