Interleukin-12 Immunomodulation Delays the Onset of Lethal Peritoneal Disease of Ovarian Cancer.

作者: Courtney A. Cohen , Amanda A. Shea , C. Lynn Heffron , Eva M. Schmelz , Paul C. Roberts

DOI: 10.1089/JIR.2015.0049

关键词:

摘要: … IL-12 (mbIL-12). Using an mbIL-12-expressing cell variant, we demonstrate that localized IL-12 … challenge, indicating that IL-12 did not impact the immunogenicity of the cancer cells. Our …

参考文章(48)
Alain H. Rook, Gary S. Wood, Elisa K. Yoo, Rosalie Elenitsas, David M.F. Kao, Matthew L. Sherman, William K. Witmer, Kenneth A. Rockwell, Ryan B. Shane, Stuart R. Lessin, Eric C. Vonderheid, Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses. Blood. ,vol. 94, pp. 902- 908 ,(1999) , 10.1182/BLOOD.V94.3.902.415K23_902_908
Tila Khan, Connie L. Heffron, Kevin P. High, Paul C. Roberts, Tailored vaccines targeting the elderly using whole inactivated influenza vaccines bearing cytokine immunomodulators. Journal of Interferon and Cytokine Research. ,vol. 34, pp. 129- 139 ,(2014) , 10.1089/JIR.2012.0119
Roberta Mortarini, Andrea Anichini, Silvana Pilotti, Claudia Vegetti, Ilaria Bersani, Gabrina Tragni, Emilio Bajetta, Vincenzo Cerundolo, Alessandra Borri, Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12. Cancer Research. ,vol. 60, pp. 3559- 3568 ,(2000)
H. J. Zeh, H. Tahara, M. T. Lotze, U. Gubler, Paul D Robbins, W. J. Storkus, T. G. McKinney, R. D. Schreiber, L. Zitvogel, Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. Journal of Immunology. ,vol. 154, pp. 6466- 6474 ,(1995)
Jeffrey A. Sosman, Nicholas J. Vogelzang, Lynn J. Buchanan, Matthew L. Sherman, Michael B. Atkins, Janice P. Dutcher, John P. Leonard, John L. Ryan, Gerald L. Fisher, Glenn Larsen, Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production Blood. ,vol. 90, pp. 2541- 2548 ,(1997) , 10.1182/BLOOD.V90.7.2541
U. Gubler, A. S. Stern, M. K. Gately, Ping Ling, Ping Lin, Chang Su, K. Hollfelder, J. Hakimi, Y.-C. E. Pan, Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. Journal of Immunology. ,vol. 154, pp. 116- 127 ,(1995)
Malabendu Jana, Subhajit Dasgupta, Ramendra N. Saha, Xiaojuan Liu, Kalipada Pahan, Induction of tumor necrosis factor‐α (TNF‐α) by interleukin‐12 p40 monomer and homodimer in microglia and macrophages Journal of Neurochemistry. ,vol. 86, pp. 519- 528 ,(2004) , 10.1046/J.1471-4159.2003.01864.X
Herbert J. Zeh, Hideaki Tahara, Michael T. Lotze, Ueli Gubler, Stanley F. Wolf, Paul D. Robbins, Simon C. Watkins, Walter J. Storkus, Itzhak Pappo, Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Research. ,vol. 54, pp. 182- 189 ,(1994)
Jae Kwang Yoo, Jae Ho Cho, Seung Woo Lee, Young Chul Sung, IL-12 Provides Proliferation and Survival Signals to Murine CD4+T Cells Through Phosphatidylinositol 3-Kinase/Akt Signaling Pathway The Journal of Immunology. ,vol. 169, pp. 3637- 3643 ,(2002) , 10.4049/JIMMUNOL.169.7.3637
H Tahara, H D Edington, M J Brunda, S F Wolf, R D Schreiber, W J Storkus, M K Gately, M A Nalesnik, T G McKinney, C L Nastala, Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. Journal of Immunology. ,vol. 153, pp. 1697- 1706 ,(1994)