Cancer Biology and the Principles of Targeted Cancer Drug Discovery

摘要: The understanding of molecular mechanisms cancer biology has greatly increased over the past decade. Additional hallmarks cancer, such as immune tolerance and deregulation cellular energetics, have been recognized. Targeted therapy aims to interfere with every hallmark cancer. Potential novel targets are constantly being identified evaluated. Novel therapeutics that efficacious in a subset tumors on their way clinic. Biomarker strategies for patient stratification evaluation benefit critical efficient use these personalized medicines. This article gives an overview different fields targeted drug discovery validate biomarkers.