Tailored vaccines targeting the elderly using whole inactivated influenza vaccines bearing cytokine immunomodulators.
作者： Tila Khan , Connie L. Heffron , Kevin P. High , Paul C. Roberts
关键词:
摘要: Influenza and its complications disproportionately affect the elderly, leading to high morbidity mortality in this ever-increasing population. Despite widespread vaccination efforts, current influenza vaccines are less effective elderly; hence newer vaccine strategies needed improve their efficacy age group. We have previously shown that co-presentation of cytokines on surface inactivated virus particles affords better protection from lethal homotypic viral challenge young adult mice than conventional non-adjuvanted whole vaccine. Here, we determined these formulations Balb/c “aged” 17 months (“aged mice”) along with addition a membrane-bound interleukin-12 (IL-12) formulation. Our investigations found single low-dose intramuscular co-presenting IL-12 was sufficient provide enhanced subsequent as c...
sci-hub.se 参考文章(34)
Evelyna Derhovanessian, Graham Pawelec, Vaccination in the elderly Microbial Biotechnology. ,vol. 5, pp. 226- 232 ,(2012) , 10.1111/J.1751-7915.2011.00283.X
Terje Espevik, Bjørn Naume, Maurice Gately, A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells. Journal of Immunology. ,vol. 148, pp. 2429- 2436 ,(1992)
Scott A Harper, Keiji Fukuda, Timothy M Uyeki, Nancy J Cox, Carolyn B Bridges, None, Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices (ACIP) Morbidity and Mortality Weekly Report. ,vol. 55, pp. 1- 40 ,(2004)
Thomas R. Cate, Yolanda Rayford, Diane Niño, Patricia Winokur, Rebecca Brady, Robert Belshe, Wilbur Chen, Robert L. Atmar, Robert B. Couch, A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects Vaccine. ,vol. 28, pp. 2076- 2079 ,(2010) , 10.1016/J.VACCINE.2009.12.041
Janet E. McElhaney, Xin Zhou, H. Keipp Talbot, Ernst Soethout, R. Chris Bleackley, David J. Granville, Graham Pawelec, The Unmet Need in the Elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines Vaccine. ,vol. 30, pp. 2060- 2067 ,(2012) , 10.1016/J.VACCINE.2012.01.015
Peter A. Gross, The Efficacy of Influenza Vaccine in Elderly Persons Annals of Internal Medicine. ,vol. 123, pp. 518- 527 ,(1995) , 10.7326/0003-4819-123-7-199510010-00008
Noelle-Angelique M. Molinari, Ismael R. Ortega-Sanchez, Mark L. Messonnier, William W. Thompson, Pascale M. Wortley, Eric Weintraub, Carolyn B. Bridges, The annual impact of seasonal influenza in the US: Measuring disease burden and costs Vaccine. ,vol. 25, pp. 5086- 5096 ,(2007) , 10.1016/J.VACCINE.2007.03.046
Jacqueline M. Katz, Xiuhua Lu, Charles W. Todd, Mark J. Newman, A nonionic block co-polymer adjuvant (CRL1005) enhances the immunogenicity and protective efficacy of inactivated influenza vaccine in young and aged mice. Vaccine. ,vol. 18, pp. 2177- 2187 ,(2000) , 10.1016/S0264-410X(00)00022-0
T. Germann, E. Rüde, E. Schmitt, The influence of IL12 on the development of Th11 and Th2 cells and its adjuvant effect for humoral immune responses Research in Immunology. ,vol. 146, pp. 481- 486 ,(1995) , 10.1016/0923-2494(96)83020-3
Seth J Sullivan, Robert Jacobson, Gregory A Poland, Advances in the vaccination of the elderly against influenza: role of a high-dose vaccine Expert Review of Vaccines. ,vol. 9, pp. 1127- 1133 ,(2010) , 10.1586/ERV.10.117