Modulation of overload-induced inflammation by aging and anabolic steroid administration.

摘要: Aging can alter the skeletal muscle growth response induced by overload. The initiation of overload induces extracellular matrix expansion, increased cellularity, and inflammatory gene expression, which are all related to processes important for myofiber growth. These remodeling also biological targets testosterone. It is not certain how aging affects functional whether anabolic steroid administration this response. effect on during known. purpose study was determine if age altered at onset would modulate in young or older animals. Five-month 25 month F344 x BRN rats were given nandrolone decanoate (ND) (6 mg/kg bw/wk) sham injections 3 weeks, then soleus overloaded (OV) days synergist ablation. ND alone a 230% increase ED1(+) cells 5 muscle. Three OV had no cell number either age. combined with 90% ED2(+) muscle, while there treatment In 40% cells. Regardless age, TNF-alpha mRNA expression (300%) IL-6 (900%). attenuated OV-induced but both groups. induction IL-1beta 3-fold greater (1400%), compared (400%). ablated Anabolic suppress cytokine dependent.