The Use of Intravenous Infusion or Single Dose of Low-Dose Ketamine for Postoperative Analgesia: A Review of the Current Literature

摘要: Objective As an analgesic and N -methyl-D-aspartate receptor antagonist, ketamine has been increasingly used as adjunct in the management of acute perioperative pain. Although several meta-analyses have examined low-dose intravenous (IV) ketamine, they do not distinguish between different types infusions. Additionally, many clinical trials published on vary by regimen administration surgical site. This review seeks to exclusively examine evidence supporting use IV infusion for pain. Methods We searched Medline any or that were conducted 1966 November 2013. Using six equations, we left with 695 references. Of those, five 39 met criteria be included our review. These represent 2,482 patients, 1,403 whom received ketamine. then efficacy site surgery using pain scores opioid consumption endpoints. Finally, assessed safety long-term impact ketamine. Results Low-dose reduces 40%. It also lowers scores, but these findings are less clear. No major complications reported when given up 48 hours after surgery. While lends support pain, its optimal dose remain determined. Conclusions Thirty-nine a continuous bolus postoperative analgesia reduction primary endpoint. The mean (infusion rate than 1.2 mg/kg/h) is Ketamine amplitude effect following