Development and validation of RP-HPLC method for simultaneous estimation of rifampicin, isoniazid and pyrazinamide in human plasma
作者： B. Prasanthi , J. Vijaya Ratna , R. S. Ch. Phani
DOI: 10.1134/S1061934815080146
关键词:
摘要: A rapid, simple, sensitive and cost effective stability indicating high performance liquid chromatographic method for the simultaneous determination of rifampicin, isoniazid pyrazinamide in human plasma was developed validated accordance to Food Drug Administration (FDA) guidelines. The three drugs were eluted under isocratic mode using a 250 × 4.0 mm i.d., 5 μm Phenomenex ODS 2 C18 column. mobile phase composed mixture acetonitrile, methanol water ratio 30: 5: 65 (v/v, pH adjusted 5.2) at flow rate 1.0 mL/min. limits detection quantification rifampicin 0.13 0.4 μg/mL, isoniazid—0.6 1.8 μg/mL; pyrazinamide—0.5 1.6 respectively. can be successfully applied pharmacokinetic, bioavailability or bioequivalence studies combination subjects.
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