Therapeutic Monitoring of Isoniazid, Pyrazinamide and Rifampicin in Tuberculosis Patients Using LC
作者： S. Unsalan , M. Sancar , B. Bekce , P. M. Clark , T. Karagoz
DOI: 10.1365/S10337-005-0549-0
关键词:
摘要: The objective of this study was to measure plasma concentration isoniazide (INH), pyrazinamide (PZA) and rifampisin (RIF) in tuberculosis patients by using HPLC. 100 μL deproteinized adding trichloroacetic acid acetonitrile yield INH, PZA RIF respectively. They were analysed HPLC a reversed phase C18 pre-column linked 4 μm analytical column with gradient solvent programme, which delivered 3% 40% (v/v) phosphate buffer 20 min at rate 0.8 mL min−1. Signals monitored diode-array detector. Acetanilide used as internal standard. method is reproducible accurate lower limits quantification 0.6 mg L−1 for 1.5 0.7 RIF. 25 receiving daily standard therapy assayed 3 h after administration. Plasma found between 0.98 6.27 11.05 47.26 PZA, 5.09 33.20 Many the levels be sub therapeutic. This practical may monitoring drug who fail respond treatment.
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