Effect of Acute Hypercapnia on Alpha Atrial Natriuretic Peptide, Renin, Angiotensin II, Aldosterone, and Vasopressin Plasma Levels in Patients With COPD

摘要: Disturbances in hormonal systems involved sodium and water homeostasis are common during respiratory insufficiency. To investigate the role of hypercapnia, we designed a study to examine response acute hypercapnia induced at constant cardiac filling pressures without hypoxemia. Seven sedated patients with COPD receiving mechanical ventilation were studied five successive periods. Hemodynamics, arterial blood gases, plasma hormone levels (atrial natriuretic peptide, renin, angiotensin II, aldosterone, vasopressin) measured three times 60 min (52 ± 5 mm Hg) control periods, before (36 4 after (42 3 hypercapnia. During mean pulmonary pressure output increased variation other cardiorespiratory data when compared values. After variables returned values variations levels. Our results show that moderate does not significantly influence sympathetic tone remain stable. We suggest changes those hormones salt secondary hemodynamic by failure per se.