Relationship between Pulmonary Hemodynamics and Arterial pH and Carbon Dioxide Tension in Critically III Patients

作者: Jaime Figueras , Leon Stein , Victor Diez , Max Harry Weil , Herbert Shubin

DOI: 10.1378/CHEST.70.4.466

关键词:

摘要: To ascertain the clinical significance of derangements in arterial pH and carbon dioxide tension (PaCO2) modifying pulmonary pressures vascular resistance critically ill patients, relationship between these two sets variables was evaluated 75 patients. No significant differences hemodynamic values were found among patients with acidemia, a normal pH, or alkalemia, even at extreme values; there no consistent PaCO2 each measurements. In who initially had but subsequently developed acidemia also correlation changes values. We conclude that abnormalities seriously are usually due to factors other than acid-base derangements. Of practical importance is observation predictability wedge pressure from diastolic not invalidated by disturbances.

参考文章(37)
G R Barer, J R McCurrie, P Howard, The effect of carbon dioxide and changes in blood pH on pulmonary vascular resistance in cats. Clinical Science. ,vol. 32, pp. 361- 376 ,(1967)
Edward Boycks, Sybil Michaels, Max Harry Weil, Herbert Shubin, Edward P Marbach, Continuous-Flow Measurement of Lactate in Blood: A Technique Adapted for Use in the Emergency Laboratory Clinical Chemistry. ,vol. 21, pp. 113- 118 ,(1975) , 10.1093/CLINCHEM/21.1.113
A. B. Malik, B. S. L. Kidd, The independent effects of changes in H + and CO 2 concentrations on pulmonary hemodynamics of intact dogs. Canadian Journal of Physiology and Pharmacology. ,vol. 51, pp. 139- 147 ,(1973) , 10.1139/Y73-018
H. Olesen, Thermodynamics of the Cold Agglutinin Reaction Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 18, pp. 1- 15 ,(1966) , 10.3109/00365516609065601
E. Housley, S. W. Clarke, R. B. Hedworth-Whitty, J. M. Bishop, Effect of acute and chronic acidaemia and associated hypoxia on the pulmonary circulation of patients with chronic bronchitis Cardiovascular Research. ,vol. 4, pp. 482- 489 ,(1970) , 10.1093/CVR/4.4.482
Gwenda R. Barer, J. W. Shaw, Pulmonary vasodilator and vasoconstrictor actions of carbon dioxide The Journal of Physiology. ,vol. 213, pp. 633- 645 ,(1971) , 10.1113/JPHYSIOL.1971.SP009405
Helen N. Duke, PULMONARY VASOMOTOR RESPONSES OF ISOLATED PERFUSED CAT LUNGS TO ANOXIA AND HYPERCAPNIA Quarterly Journal of Experimental Physiology and Cognate Medical Sciences. ,vol. 36, pp. 75- 88 ,(1951) , 10.1113/EXPPHYSIOL.1951.SP000963
H. Shubin, M. H. Weil, M. A. Rockwell, Automated measurement of cardiac output in patients by use of a digital computer. Medical & Biological Engineering & Computing. ,vol. 5, pp. 353- 360 ,(1967) , 10.1007/BF02479099
Albert L. Hyman, William C. Woolverton, Paul S. Guth, Herbert Ichinose, The pulmonary vasopressor response to decreases in blood pH in intact dogs Journal of Clinical Investigation. ,vol. 50, pp. 1028- 1043 ,(1971) , 10.1172/JCI106574