The XPD/ERCC2, RAD51 and hOGG1 Gene Polymorphisms in Turkish Patients with Advanced-Stage Gastric Cancer
作者： Arzu Yaren , Aydın Demiray , Hakan Akça , Atike Gökçen Demiray , Özgür Tanriverdi
关键词:
摘要: Bu calismada ileri evre mide kanserli Turk hastalarda XPD/ERCC2, RAD51 ve hOGG1 gen polimorfizminin prognoz uzerine etkisinin olup olmadigini degerlendirdik. Calismaya performans durumu 0-2 olan, inoperabl lokal veya uzak metastazli 31 kanseri hastasi ile kontrol grubu olarak 29 saglikli birey dahil edildi. DNA serumdan izole edildikten sonra tek nukleotid polimorfizmi MassARRAY Analyzer 4 System [Sequenom] kullanilarak analiz Gozlenen genotip frekanslarinin istatistiksel degeri beklenen frekanslarina kiyasla Hardy-Weinberg kuralina gore belirlendi. Hasta grubunda ortanca yas 68 (yil) hastalarin %74’u erkek, %26’si kadin idi. XPD/ERCC2 Asp312Asn [rs1799793] nukleotit G23591A, [rs1801320] G135C Ser 326 Cys [rs1052133] poliforfizmi tespit Mide genotipler arasinda anlamli bir iliski kuramadik.
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