Nuclear Factor-kB Tumor Expression Predicts Response and Survival in Irinotecan-Refractory Metastatic Colorectal Cancer Treated With Cetuximab-Irinotecan Therapy
作者： Mario Scartozzi , Italo Bearzi , Chiara Pierantoni , Alessandra Mandolesi , Fotios Loupakis
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摘要: Purpose NF-kB expression has been shown to be responsible for resistance antineoplastic agents and it also plays a part in the activation of epidermal growth factor receptor downstream signaling pathway colorectal tumors. The aim our analysis was investigate correlation between expression, response rate, time progression, survival advanced cancer patients receiving cetuximab irinotecan. Patients Methods We analyzed retrospectively immunoreactivity irinotecan-refractory Results Seventy-six were analyzed. Cetuximab irinotecan administered as second-line chemotherapy 19 after ≥ two lines remaining 57 patients. observed partial (PR) 16 an overall rate 24%. Thirty-two (48%) experienced progressive disease; median progression (TTP) 3.6 months 10.3 m...
jco.org参考文章(23)
Amyn A. Habib, Sukalyan Chatterjee, Song-Kyu Park, Rajiv R. Ratan, Sharon Lefebvre, Timothy Vartanian, The Epidermal Growth Factor Receptor Engages Receptor Interacting Protein and Nuclear Factor-κB (NF-κB)-inducing Kinase to Activate NF-κB IDENTIFICATION OF A NOVEL RECEPTOR-TYROSINE KINASE SIGNALOSOME Journal of Biological Chemistry. ,vol. 276, pp. 8865- 8874 ,(2001) , 10.1074/JBC.M008458200
Hirotaka Nishi, Gila Neta, Katsura Nishi, Latania Akers, Toshiki Rikiyama, Kimberle Proctor, Barbara Murphy, Alfred Johnson, Analysis of the epidermal growth factor receptor promoter: The effect of nuclear factor-κB International Journal of Molecular Medicine. ,vol. 11, pp. 49- 55 ,(2003) , 10.3892/IJMM.11.1.49
Xavier Dolcet, David Llobet, Judit Pallares, Xavier Matias-Guiu, None, NF-kB in development and progression of human cancer Virchows Archiv. ,vol. 446, pp. 475- 482 ,(2005) , 10.1007/S00428-005-1264-9
Mohamed M. M. Abdel-Latif, James O??Riordan, Henry J. Windle, Eleanor Carton, Nagunivan Ravi, Dermot Kelleher, John V. Reynolds, NF-kappaB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy Annals of Surgery. ,vol. 239, pp. 491- 500 ,(2004) , 10.1097/01.SLA.0000118751.95179.C6
Kiichi Hirota, Miyahiko Murata, Tatsuya Itoh, Junji Yodoi, Kazuhiko Fukuda, Redox-sensitive Transactivation of Epidermal Growth Factor Receptor by Tumor Necrosis Factor Confers the NF-κB Activation Journal of Biological Chemistry. ,vol. 276, pp. 25953- 25958 ,(2001) , 10.1074/JBC.M011021200
D.Scott Lind, Steven N. Hochwald, John Malaty, Stelio Rekkas, Paul Hebig, Girish Mishra, Lyle L. Moldawer, Edward M. Copeland, Sally MacKay, Nuclear factor-κB is upregulated in colorectal cancer Surgery. ,vol. 130, pp. 363- 369 ,(2001) , 10.1067/MSY.2001.116672
Mario Scartozzi, Italo Bearzi, Rossana Berardi, Alessandra Mandolesi, Guidalberto Fabris, Stefano Cascinu, Epidermal Growth Factor Receptor (EGFR) Status in Primary Colorectal Tumors Does Not Correlate With EGFR Expression in Related Metastatic Sites: Implications for Treatment With EGFR-Targeted Monoclonal Antibodies Journal of Clinical Oncology. ,vol. 22, pp. 4772- 4778 ,(2004) , 10.1200/JCO.2004.00.117
Yumi Yamamoto, Richard B. Gaynor, Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer Journal of Clinical Investigation. ,vol. 107, pp. 135- 142 ,(2001) , 10.1172/JCI11914
Guido M Sclabas, Shuichi Fujioka, Christian Schmidt, Zhen Fan, Douglas B Evans, Paul J Chiao, Restoring Apoptosis in Pancreatic Cancer Cells by Targeting the Nuclear Factor-κB Signaling Pathway With the Anti-Epidermal Growth Factor Antibody IMC-C225 Journal of Gastrointestinal Surgery. ,vol. 7, pp. 37- 43 ,(2003) , 10.1016/S1091-255X(02)00088-4
Lee M. Ellis, Paulo M. Hoff, Targeting the Epidermal Growth Factor Receptor: An Important Incremental Step in the Battle Against Colorectal Cancer Journal of Clinical Oncology. ,vol. 22, pp. 1177- 1179 ,(2004) , 10.1200/JCO.2004.01.971