Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak.

摘要: Disorders of calcium metabolism are not generally considered important either clinically or pathophysiologically in essential hypertension. Recent reports, though, suggest that increased parathyroid gland function may be one the more common endocrine disturbances associated with We measured serum hormone (PTH) concentrations as well routine blood and urine chemistries 34 hypertensives. Their mean PTH, 79.1 +/- 3.1 muliter Eq/muliter, was significantly higher (p less than 0.025) 66.9 3.3, an age- sex-matched normotensive control population. The calcium, 9.5 0.1 mg%, identical two populations. Compared to a second population, hypertensives demonstrated significant 0.005) relative hypercalciuria. For any level urinary sodium, excreted calcium. These preliminary data enhanced This activity appears, part, appropriate, physiologic response previously unrecognized hypercalciuria, renal leak, conclude prevalence hypertension subjects hyperparathyroidism probably represents final event continuum begins obligatory losses hypertensives, but whose pathological presentation is hyperparathyroidism. results this pilot study indicate need for derivative experiments directed at defining importance our findings pathogenesis human experimental