摘要: Abstract DNA methylation plays an important role in controlling gene-expression programs. Increasing evidence indicates that the enzyme responsible for replicating pattern, methyltransferase 1 (DNMT1), has a cancer. In this article, it is suggested DNMT1 multifunctional protein regulatory activities addition to activity. These functions are assembled into one ensure coordinate replication of and its pattern. The proposed be involved cellular transformation should, theore, serve as targets novel anti-cancer agents.
unirioja.es
elsevier.com
sci-hub.se 参考文章(51)
Moshe Szyf, Targeting DNA methyltransferase in cancer. Cancer and Metastasis Reviews. ,vol. 17, pp. 219- 231 ,(1998) , 10.1023/A:1006023023787
Michael R. Rountree, Kurtis E. Bachman, Stephen B. Baylin, DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci Nature Genetics. ,vol. 25, pp. 269- 277 ,(2000) , 10.1038/77023
Laurie Jackson-Grusby, Caroline Beard, Richard Possemato, Matthew Tudor, Douglas Fambrough, Györgyi Csankovszki, Jessica Dausman, Peggy Lee, Christopher Wilson, Eric Lander, Rudolf Jaenisch, Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nature Genetics. ,vol. 27, pp. 31- 39 ,(2001) , 10.1038/83730
Keith D. Robertson, Slimane Ait-Si-Ali, Tomoki Yokochi, Paul A. Wade, Peter L. Jones, Alan P. Wolffe, DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters Nature Genetics. ,vol. 25, pp. 338- 342 ,(2000) , 10.1038/77124
Ina Rhee, Kam-Wing Jair, Ray-Whay Chiu Yen, Christoph Lengauer, James G. Herman, Kenneth W. Kinzler, Bert Vogelstein, Stephen B. Baylin, Kornel E. Schuebel, CpG methylation is maintained in human cancer cells lacking DNMT1 Nature. ,vol. 404, pp. 1003- 1007 ,(2000) , 10.1038/35010000
François Fuks, Wendy A. Burgers, Alexander Brehm, Luke Hughes-Davies, Tony Kouzarides, DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genetics. ,vol. 24, pp. 88- 91 ,(2000) , 10.1038/71750
M. Szyf, V. Bozovic, G. Tanigawa, Growth regulation of mouse DNA methyltransferase gene expression. Journal of Biological Chemistry. ,vol. 266, pp. 10027- 10030 ,(1991) , 10.1016/S0021-9258(18)99179-9
Jean-Pierre Jost, Michel Siegmann, Lijie Sun, Roland Leung, Mechanisms of DNA Demethylation in Chicken Embryos: PURIFICATION AND PROPERTIES OF A 5-METHYLCYTOSINE-DNA GLYCOSYLASE (∗) Journal of Biological Chemistry. ,vol. 270, pp. 9734- 9739 ,(1995) , 10.1074/JBC.270.17.9734
J.C. Wu, D.V. Santi, Kinetic and catalytic mechanism of HhaI methyltransferase. Journal of Biological Chemistry. ,vol. 262, pp. 4778- 4786 ,(1987) , 10.1016/S0021-9258(18)61263-3
Mark L Gonzalgo, Toshiro Hayashida, Christina M Bender, Martha M Pao, Yvonne C Tsai, Felicidad A Gonzales, Hung D Nguyen, TuDung T Nguyen, Peter A Jones, None, The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines Cancer Research. ,vol. 58, pp. 1245- 1252 ,(1998)