Role and expression of neurotrophins and the trk family of tyrosine kinase receptors in neural growth and rescue after injury.

摘要: Molecular cloning of genes for the neurotrophin family and identification their high-affinity receptors have recently contributed to our understanding neurotrophic interactions in vertebrate nervous system. From primary sites synthesis, novel neuronal populations that may be sensitive neurotrophins been identified. Protective roles these factors following epileptic, ischemic, hypoglycemic insults inferred. Documented actions on basal forebrain cholinergic neurons mesencephalic dopaminergic imply future clinical applications treatment dementia both Alzheimer's Parkinson's disease. Studies structure-function relationships hold promises development specific receptor agonists antagonists with possible basic science applications.