Regulation of neurotrophin receptor expression during embryonic and postnatal development.

摘要: Members of the NGF family proteins act as neurotrophic agents for defined populations peripheral and central neurons during embryonic postnatal development. We have studied presence receptors brain-derived factor (BDNF) neurotrophin-3 -4/5 (NT-3, NT-4/5) by cross-linking radioiodinated neurotrophins to specific cell surface receptors. identified neurotrophin representing full-length TrkB TrkC their truncated forms (lacking a functional cytoplasmic kinase domain) in neuronal well non-neuronal tissues. During chicken early brain development, expression preceded onset these A similar pattern was also observed mouse brain. The relative levels basal forebrain hippocampus did not change significantly with age mice. High three were detected nigrostriatal system. Full-length found rat ventral spinal cord, on purified motoneurons. Again, appeared later than form In retina optic tectum we TrkC; however, expressed large amounts TrkB. but skeletal muscle, suggesting that NT-3 may novel function this tissue. wide variety tissues underlines significant role BDNF, NT-3, NT-4/5 regulation ratio versus play an important maturation, maintenance various networks.