High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types.

作者: DJ McGrail , PG Pilié , NU Rashid , L Voorwerk , M Slagter

DOI: 10.1016/J.ANNONC.2021.02.006

关键词:

摘要: … predicted neoantigen load and CD8 T cells. Association of TMB with ICB treatment outcomes was analyzed by both objective response rates (ORRs, N = 1551) and overall survival (OS, …

参考文章(61)
Andrew J Gentles, Aaron M Newman, Chih Long Liu, Scott V Bratman, Weiguo Feng, Dongkyoon Kim, Viswam S Nair, Yue Xu, Amanda Khuong, Chuong D Hoang, Maximilian Diehn, Robert B West, Sylvia K Plevritis, Ash A Alizadeh, The prognostic landscape of genes and infiltrating immune cells across human cancers Nature Medicine. ,vol. 21, pp. 938- 945 ,(2015) , 10.1038/NM.3909
Matthew M. Gubin, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Tumor neoantigens: building a framework for personalized cancer immunotherapy Journal of Clinical Investigation. ,vol. 125, pp. 3413- 3421 ,(2015) , 10.1172/JCI80008
Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596
Beate Pesch, Benjamin Kendzia, Per Gustavsson, Karl-Heinz Jöckel, Georg Johnen, Hermann Pohlabeln, Ann Olsson, Wolfgang Ahrens, Isabelle Mercedes Gross, Irene Brüske, Heinz-Erich Wichmann, Franco Merletti, Lorenzo Richiardi, Lorenzo Simonato, Cristina Fortes, Jack Siemiatycki, Marie-Elise Parent, Dario Consonni, Maria Teresa Landi, Neil Caporaso, David Zaridze, Adrian Cassidy, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Isabelle Stücker, Eleonora Fabianova, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Charles M. Rudin, Paul Brennan, Paolo Boffetta, Kurt Straif, Thomas Brüning, Cigarette smoking and lung cancer – relative risk estimates for the major histological types from a pooled analysis of case-control studies International Journal of Cancer. ,vol. 131, pp. 1210- 1219 ,(2012) , 10.1002/IJC.27339
K. Wang, M. Li, H. Hakonarson, ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data Nucleic Acids Research. ,vol. 38, ,(2010) , 10.1093/NAR/GKQ603
Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz, Nir Hacohen, Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. ,vol. 160, pp. 48- 61 ,(2015) , 10.1016/J.CELL.2014.12.033
Naiyer A. Rizvi, Matthew D. Hellmann, Alexandra Snyder, Pia Kvistborg, Vladimir Makarov, Jonathan J. Havel, William Lee, Jianda Yuan, Phillip Wong, Teresa S. Ho, Martin L. Miller, Natasha Rekhtman, Andre L. Moreira, Fawzia Ibrahim, Cameron Bruggeman, Billel Gasmi, Roberta Zappasodi, Yuka Maeda, Chris Sander, Edward B. Garon, Taha Merghoub, Jedd D. Wolchok, Ton N. Schumacher, Timothy A. Chan, Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer Science. ,vol. 348, pp. 124- 128 ,(2015) , 10.1126/SCIENCE.AAA1348
H. Li, R. Durbin, Fast and accurate short read alignment with Burrows–Wheeler transform Bioinformatics. ,vol. 25, pp. 1754- 1760 ,(2009) , 10.1093/BIOINFORMATICS/BTP324
Pablo Cingolani, Adrian Platts, Le Lily Wang, Melissa Coon, Tung Nguyen, Luan Wang, Susan J. Land, Xiangyi Lu, Douglas M. Ruden, A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3 Fly. ,vol. 6, pp. 80- 92 ,(2012) , 10.4161/FLY.19695
A. McKenna, M. Hanna, E. Banks, A. Sivachenko, K. Cibulskis, A. Kernytsky, K. Garimella, D. Altshuler, S. Gabriel, M. Daly, M. A. DePristo, The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data Genome Research. ,vol. 20, pp. 1297- 1303 ,(2010) , 10.1101/GR.107524.110