BATF Interference Blocks Th17 Cell Differentiation and Inflammatory Response in Hepatitis B Virus Transgenic Mice

摘要: B cell-activating transcription factor (BATF) contributes to Th17 cell differentiation and pathological inflammatory responses. This study explored BATF as a regulator of in normal hepatitis virus (HBV) transgenic mice. Normal mice were divided into control, short hairpin RNA (shRNA) scramble, shRNA groups. HBV entecavir, entecavir + vector entecavir + shRNA BATF, Serum concentrations AST, ALT, HBV-DNA, IL-17, IL-22 frequencies the liver compared among Correlations serum surface antigen (HBsAg), e-antigen (HBeAg), core (HBcAg) with mRNA expression proportion cells livers also analyzed. proportions higher relative controls. Positive correlations HBcAg concentration observed interference reduced IL-17 led obvious downregulation when combined entecavir. markedly upregulated promoted activation. By contrast, significantly impeded proliferation secretion while alleviating hepatic lesions.