Detection of Botulinum Neurotoxins Using Optical Fiber-Based Biosensor
作者： Bal Ram Singh , Melissa A. Silvia
DOI: 10.1007/978-1-4613-0361-9_40
关键词:
摘要: Botulinum neurotoxins, produced by the anaerobic bacterium Clostridium botulinum, are most toxic poisons known to man. The neurotoxins food poisons. Once ingested, neurotoxin is absorbed through intestinal mucosal layer into blood stream. It acts at neuromuscular junction inhibit release of acetylcholine (a neurotransmitter) from nerve endings (Simpson, 1989). result dreaded botulism disease, which manifested flaccid muscle paralysis.
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sci-hub.st 参考文章(24)
Stephen S. Arnon, Clinical Trial of Human Botulism Immune Globulin Springer, Boston, MA. pp. 477- 482 ,(1993) , 10.1007/978-1-4757-9542-4_53
Lance L. Simpson, Botulinum neurotoxin and tetanus toxin Academic Press. ,(1989)
Biomedical Aspects, Bibhuti R. DasGupta, Botulinum and Tetanus Neurotoxins: Neurotransmission And Biomedical Aspects ,(2013)
C Shone, P Wilton-Smith, N Appleton, P Hambleton, N Modi, S Gatley, J Melling, Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay. Applied and Environmental Microbiology. ,vol. 50, pp. 63- 67 ,(1985) , 10.1128/AEM.50.1.63-67.1985
G J Doellgast, M X Triscott, G A Beard, J D Bottoms, T Cheng, B H Roh, M G Roman, P A Hall, J E Brown, Sensitive enzyme-linked immunosorbent assay for detection of Clostridium botulinum neurotoxins A, B, and E using signal amplification via enzyme-linked coagulation assay. Journal of Clinical Microbiology. ,vol. 31, pp. 2402- 2409 ,(1993) , 10.1128/JCM.31.9.2402-2409.1993
I Ohishi, S Sugii, G Sakaguchi, Oral toxicities of Clostridium botulinum toxins in response to molecular size. Infection and Immunity. ,vol. 16, pp. 107- 109 ,(1977) , 10.1128/IAI.16.1.107-109.1977
Anthony C. Ashton, John S. Crowther, J.Oliver Dolly, A sensitive and useful radioimmunoassay for neurotoxin and its haemagglutinin complex from Clostridium botulinum. Toxicon. ,vol. 23, pp. 235- 246 ,(1985) , 10.1016/0041-0101(85)90146-1
Nobuhiro Fujii, Kouichi Kimura, Noriko Yokosawa, Keiji Oguma, Teruo Yashiki, Kouichi Takeshi, Touru Ohyama, Emiko Isogai, Hiroshi Isogai, Similarity in nucleotide sequence of the gene encoding nontoxic component of botulinum toxin produced by toxigenic Clostridium butyricum strain BL6340 and Clostridium botulinum type E strain Mashike. Microbiology and Immunology. ,vol. 37, pp. 395- 398 ,(1993) , 10.1111/J.1348-0421.1993.TB03227.X
Robert A. Ogert, J. Edward Brown, Bal Ram Singh, Lisa C. Shriver-Lake, Frances S. Ligler, Detection of Clostridium botulinum toxin A using a fiber optic-based biosensor. Analytical Biochemistry. ,vol. 205, pp. 306- 312 ,(1992) , 10.1016/0003-2697(92)90440-I
Suresh K. Bhatia, Lisa C. Shriver-Lake, Kimberly J. Prior, Jacque H. Georger, Jeffrey M. Calvert, Reinhard Bredehorst, Frances S. Ligler, Use of thiol-terminal silanes and heterobifunctional crosslinkers for immobilization of antibodies on silica surfaces. Analytical Biochemistry. ,vol. 178, pp. 408- 413 ,(1989) , 10.1016/0003-2697(89)90662-3