Cross-species-specific cd3-epsilon binding domain
作者： Matthias Klinger , Doris Rau , Susanne Mangold , Roman Kischel , Peter Kufer
DOI:
关键词:
摘要: The present invention relates to a polypeptide comprising human binding domain capable of an epitope and non-chimpanzee primate CD3 (epsilon) chain as well process for the production mentioned polypeptide. further nucleic acids encoding polypeptide, vectors same host cells vector. In another aspect, provides pharmaceutical composition medical uses aspect method identification polypeptides cross-species specific CD3e (CD3 epsilon).
lens.org参考文章(13)
Ronny Cierpka, Majk Kvesic, Carola Steiger, Mirnaalini Sriskandarajah, Matthias Klinger, Evelyn Ebert, Doris Rau, Evelyne Schaller, Susanne Strasser, Susanne Mangold, Susanne Hausmann, Roman Kischel, Peter Kufer, Petra Meier, Claudia Blümel, Sandra Wissing, Petra Mayer, Patrick Hoffmann, Tobias Raum, Ralf Lutterbüse, Gert Riethmüller, Elke Burghart, Cross-species-specific bispecific binders ,(2008)
M S Cole, J Y Tso, C Anasetti, Human IgG2 variants of chimeric anti-CD3 are nonmitogenic to T cells. Journal of Immunology. ,vol. 159, pp. 3613- 3621 ,(1997)
Yann Dean, Marie Kosco-Vilbois, Greg Elson, Anti-cd3 antibody formulations ,(2006)
Klaus Brischwein, Larissa Parr, Stefan Pflanz, Jörg Volkland, John Lumsden, Matthias Klinger, Mathias Locher, Scott A. Hammond, Peter Kiener, Peter Kufer, Bernd Schlereth, Patrick A. Baeuerle, Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class. Journal of Immunotherapy. ,vol. 30, pp. 798- 807 ,(2007) , 10.1097/CJI.0B013E318156750C
Ligia da Costa, Christoph Renner, Frank Hartmann, Michael Pfreundschuh, Immune recruitment by bispecific antibodies for the treatment of Hodgkin disease. Cancer Chemotherapy and Pharmacology. ,vol. 46, ,(2000) , 10.1007/PL00014047
Hiroki Hayashi, Ryutaro Asano, Kouhei Tsumoto, Yu Katayose, Masanori Suzuki, Michiaki Unno, Hideaki Kodama, Shin-ichi Takemura, Hiroshi Yoshida, Koki Makabe, Kohzoh Imai, Seiki Matsuno, Izumi Kumagai, Toshio Kudo, A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells Cancer Immunology, Immunotherapy. ,vol. 53, pp. 497- 509 ,(2004) , 10.1007/S00262-003-0465-9
Kathryn M. Kodier, Chi-Huey Wong, Synthesis and Applications of Biologically Relevant Glycopeptides ChemInform. ,vol. 34, pp. 2305- 2352 ,(2001) , 10.1007/978-3-642-56874-9_56
Peter I Lobo, Hirenkumar C Patel, Murine monoclonal IgG antibodies: differences in their IgG isotypes can affect the antibody effector activity when using human cells. Immunology and Cell Biology. ,vol. 75, pp. 267- 274 ,(1997) , 10.1038/ICB.1997.41
Bernd Schlereth, Doris Rau, Roman Kischel, Peter Kufer, Ronny Cierpka, Tobias Raum, Compositions comprising cross-species-specific antibodies and uses thereof ,(2006)
Yann Dean, Olivier Leger, Nicolas Fischer, Marie Kosco-Vilbois, Bernard Mach, Greg Christopher Andrew Elson, Anti-CD3 Antibodies And Methods Of Use Thereof ,(2005)