Cross-species-specific bispecific binders
作者： Ronny Cierpka , Majk Kvesic , Carola Steiger , Mirnaalini Sriskandarajah , Matthias Klinger
DOI:
关键词:
摘要: The present invention relates to a polypeptide comprising first human binding domain capable of an epitope and non-chimpanzee primate CD3 (epsilon) chain second EGFR, Her2/neu or IgE and/or as well process for the production mentioned polypeptide. further nucleic acids encoding polypeptide, vectors same host cells vector. In another aspect, provides pharmaceutical composition medical uses
lens.org参考文章(18)
Ed Harlow, David Lane, Using Antibodies: A Laboratory Manual ,(1998)
Vassilios Papadopoulos, Thierry Hauet, Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration ,(2003)
David Lane, Ed Harlow, Antibodies: A Laboratory Manual ,(1988)
Gregory Lazar, Philip Hammond, John Desjarlais, Wei Dang, Jost Vielmetter, Optimized proteins that target the epidermal growth factor receptor ,(2004)
Gerald L. Rowley, Edwin F. Ullman, Ian Gibbons, Robert F. Zuk, Double antibody for enhanced sensitivity in immunoassay ,(1979)
James D. Marks, Robert Schier, High affinity human antibodies to tumor antigens ,(1996)
John B. Ridgway, Paul J. Carter, Leonard G. Presta, A method for making heteromultimeric polypeptides ,(1996)
Yann Dean, Marie Kosco-Vilbois, Greg Elson, Anti-cd3 antibody formulations ,(2006)
Hiroki Hayashi, Ryutaro Asano, Kouhei Tsumoto, Yu Katayose, Masanori Suzuki, Michiaki Unno, Hideaki Kodama, Shin-ichi Takemura, Hiroshi Yoshida, Koki Makabe, Kohzoh Imai, Seiki Matsuno, Izumi Kumagai, Toshio Kudo, A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells Cancer Immunology, Immunotherapy. ,vol. 53, pp. 497- 509 ,(2004) , 10.1007/S00262-003-0465-9
Bernd Schlereth, Doris Rau, Roman Kischel, Peter Kufer, Ronny Cierpka, Tobias Raum, Compositions comprising cross-species-specific antibodies and uses thereof ,(2006)