Fibroblast selection in scleroderma

摘要: Human preputial skin fibroblasts were cloned in vitro, and studies 21 clones shown to exhibit a 3-fold difference collagen synthesis; this heterogeneity of phenotypic expression was conserved over multiple population doublings. When the exposed sera from 10 scleroderma patients, selective growth high-collagen-producing observed. Prostaglandin E2 abrogated effect serum on fibroblast clones. Besides enhanced synthesis, these normal shared an insensitivity feeding schedule with skin. These data raise possibility that represents process selection programmed produce increased amounts collagen.