Structure-Activity Relationships in Fusidic Acid-Type Antibiotics
作者： W. Von Daehne , W.O. Godtfredsen , P.R. Rasmussen
DOI: 10.1016/S0065-2164(08)70148-5
关键词:
摘要: Publisher Summary Some of the naturally occurring fusidic acid-related antibiotics include helvolic acid, cephalosporin P family, and formed by Fusidium coccineum. Helvolic acid contains same skeleton as but substitution pattern rings A, B, C is different. Its antibacterial properties are qualitatively similar to those acid. Fusidic inhibits in vivo vitro protein synthesis both prokaryotic eukaryotic cells. In Staphylococcus aureus , two types resistance may occur. One these involves chromosomal mutations giving rise modification protein-synthesizing machinery. The other type known occur staphylococci plasmid mediated. This results from exclusion antibiotic bacterial cell. It has been observed that structure–activity relationships among 16-deacetoxy-16β-alkylthiofusidic acids very 16β-alkoxy series.
sci-hub.se 参考文章(41)
H. S. Burton, E. P. Abraham, Isolation of antibiotics from a species of Cephalosporium; cephalosporins P1, P2, P3, P4, and P5. Biochemical Journal. ,vol. 50, pp. 168- 174 ,(1951) , 10.1042/BJ0500168
W. Godtfredsen, K. Roholt, L. Tybring, Fucidin: a new orally active antibiotic. The Lancet. ,vol. 279, pp. 928- 931 ,(1962) , 10.1016/S0140-6736(62)91968-2
W. O. Godtfredsen, Fusidic acid and some related antibiotics [s.n.]. ,(1967)
Shigenobu Okuda, Shigeo Iwasaki, Kyosuke Tsuda, Yoshimoto Sano, Toju Hata, Shunichi Udagawa, Yuya Nakayama, Hiroshi Yamaguchi, THE STRUCTURE OF HELVOLIC ACID. Chemical & Pharmaceutical Bulletin. ,vol. 12, pp. 121- 124 ,(1964) , 10.1248/CPB.12.121
Alberto Bernardi, Philip Leder, Protein Biosynthesis in Escherichia coli PURIFICATION AND CHARACTERISTICS OF A MUTANT G FACTOR Journal of Biological Chemistry. ,vol. 245, pp. 4263- 4268 ,(1970) , 10.1016/S0021-9258(19)63789-0
James W. Bodley, Franklin J. Zieve, Lillian Lin, Studies on translocation. IV. The hydrolysis of a single round of guanosine triphosphate in the presence of fusidic acid. Journal of Biological Chemistry. ,vol. 245, pp. 5662- 5667 ,(1970) , 10.1016/S0021-9258(18)62705-X
G. R. Miller, Fusidic-acid-resistant staphylococci. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology. ,vol. 37, pp. 313- 317 ,(1971) , 10.1007/BF02218502
A. Cooper, D.C. Hodgkin, The crystal structure and absolute configuration of fusidic acid methyl ester 3-p-bromobenzoate Tetrahedron. ,vol. 24, pp. 909- 922 ,(1968) , 10.1016/0040-4020(68)88041-X
Nathan Brot, Carlos Spears, Herbert Weissbach, The interaction of transfer factor G, ribosomes, and guanosine nucleotides in the presence of fusidic acid Archives of Biochemistry and Biophysics. ,vol. 143, pp. 286- 296 ,(1971) , 10.1016/0003-9861(71)90211-6
D. Arigoni, W. von Daehne, W. O. Godtfredsen, Andrée Marquet, A. Melera, THE LOCATION OF THE RING C HYDROXYL GROUP IN FUSIDIC ACID. Cellular and Molecular Life Sciences. ,vol. 19, pp. 521- 522 ,(1963) , 10.1007/BF02150888