The interaction of transfer factor G, ribosomes, and guanosine nucleotides in the presence of fusidic acid
作者： Nathan Brot , Carlos Spears , Herbert Weissbach
DOI: 10.1016/0003-9861(71)90211-6
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摘要: Abstract The reaction of factor G, ribosomes, and GTP to form a ternary complex has been investigated. formation the is associated with hydrolysis amount resulting ribosome-G-GDP formed increased in presence fusidic acid. In addition, acid, stoichiometry observed between GDP bound hydrolyzed. analog guanylyl-5′-methylenediphosphonate (GDPCP) can also G ribosomes but this unaffected by It suggested that mechanism action acid stabilize G-ribosome-GDP prevent its dissociation. All above reactions take place on 50S ribosomal subunit.
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