Tetraspanins CD9 and CD151 at the immune synapse support T‐cell integrin signaling
作者： Vera Rocha-Perugini , José Maria González-Granado , Emilio Tejera , Soraya López-Martín , Maria Yañez-Mó
关键词:
摘要: Understanding how the immune response is activated and amplified requires detailed knowledge of stages in formation immunological synapse (IS) between T lymphocytes antigen-presenting cells (APCs). We show that tetraspanins CD9 CD151 congregate at T-cell side IS. Silencing or blunts IL-2 secretion expression activation marker CD69 by APC-conjugated lymphocytes, but does not affect accumulation CD3 actin to IS, translocation microtubule-organizing center toward T-B contact area. silencing diminishes relocalization α4β1 integrin IS reduces high-affinity β1 integrins cell-cell contact. These changes are accompanied diminished phosphorylation downstream targets FAK ERK1/2. Our results suggest support integrin-mediated signaling
sci-hub.se 参考文章(26)
Tadashi Yokosuka, Takashi Saito, The immunological synapse, TCR microclusters, and T cell activation. Current Topics in Microbiology and Immunology. ,vol. 340, pp. 81- 107 ,(2010) , 10.1007/978-3-642-03858-7_5
Cécile Lagaudrière-Gesbert, Alix Delaguillaumie, Hélène Conjeaud, Michel R. Popoff, Michel R. Popoff, Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes. Journal of Cell Science. ,vol. 115, pp. 433- 443 ,(2002) , 10.1242/JCS.115.2.433
Jan Herter, Alexander Zarbock, Integrin Regulation during Leukocyte Recruitment Journal of Immunology. ,vol. 190, pp. 4451- 4457 ,(2013) , 10.4049/JIMMUNOL.1203179
Fedor Berditchevski, Complexes of tetraspanins with integrins: more than meets the eye Journal of Cell Science. ,vol. 114, pp. 4143- 4151 ,(2001) , 10.1242/JCS.114.23.4143
Sara W. Feigelson, Valentin Grabovsky, Revital Shamri, Shoshana Levy, Ronen Alon, The CD81 Tetraspanin Facilitates Instantaneous Leukocyte VLA-4 Adhesion Strengthening to Vascular Cell Adhesion Molecule 1 (VCAM-1) under Shear Flow Journal of Biological Chemistry. ,vol. 278, pp. 51203- 51212 ,(2003) , 10.1074/JBC.M303601200
Takeo Iwasaki, Yoshito Takeda, Kazuichi Maruyama, Yasuyuki Yokosaki, Kazuyuki Tsujino, Satoshi Tetsumoto, Hanako Kuhara, Kaori Nakanishi, Yasushi Otani, Yingji Jin, Satoshi Kohmo, Haruhiko Hirata, Ryo Takahashi, Mayumi Suzuki, Koji Inoue, Izumi Nagatomo, Sho Goya, Takashi Kijima, Toru Kumagai, Isao Tachibana, Ichiro Kawase, Atsushi Kumanogoh, Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. Journal of Biological Chemistry. ,vol. 288, pp. 2118- 2131 ,(2013) , 10.1074/JBC.M112.424291
Jacqueline M. Tarrant, Lorraine Robb, Annemiek B. van Spriel, Mark D. Wright, Tetraspanins: molecular organisers of the leukocyte surface. Trends in Immunology. ,vol. 24, pp. 610- 617 ,(2003) , 10.1016/J.IT.2003.09.011
Emilio Tejera, Vera Rocha-Perugini, Soraya López-Martín, Daniel Pérez-Hernández, Alexia I. Bachir, Alan Rick Horwitz, Jesús Vázquez, Francisco Sánchez-Madrid, María Yáñez-Mo, CD81 regulates cell migration through its association with Rac GTPase. Molecular Biology of the Cell. ,vol. 24, pp. 261- 273 ,(2013) , 10.1091/MBC.E12-09-0642
Brandon J. Burbach, Ricardo B. Medeiros, Kristen L. Mueller, Yoji Shimizu, T-cell receptor signaling to integrins Immunological Reviews. ,vol. 218, pp. 65- 81 ,(2007) , 10.1111/J.1600-065X.2007.00527.X
In-Kee Hong, Doo-Il Jeoung, Kwon-Soo Ha, Young-Myeong Kim, Hansoo Lee, Tetraspanin CD151 Stimulates Adhesion-dependent Activation of Ras, Rac, and Cdc42 by Facilitating Molecular Association between β1 Integrins and Small GTPases Journal of Biological Chemistry. ,vol. 287, pp. 32027- 32039 ,(2012) , 10.1074/JBC.M111.314443