The neurobiology of canine distemper virus infection

摘要: Canine distemper virus (CDV) invades the nervous system and replicates in neurons glial cell of white matter during a period severe viral induced immunosuppression. Demyelination occurs infected areas absence inflammation. The mechanism demyelination is not apparent because there no ultrastructural evidence replication oligodendrocytes, myelin producing cells. However, brain tissue culture studies have shown that oligodendrocytes support transcription all CDV genes later on degenerate, although proteins can be found these It remains to how such restricted infection leads demyelination. Concomitant with immunologic recovery further course disease, inflammation demyelinating lesions progression some animals. A series experiments vitro suggested chronic due bystander associated virus-induced immune response which antibody dependent cell-mediated reactions play an important role. progressive, or even relapsing, disease persistence system. Persistence appears non-cytolytic selective spread very limited budding. In this way escapes surveillance.