作者: Louis E.-C. Leong , Christopher T. Cornell , Bert L. Semler
DOI: 10.1128/9781555817916.CH16
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摘要: Picornaviruses employ a number of unique intracellular mechanisms and novel processes during their infectious cycles resulting in being among the most successful viral pathogens. This chapter begins with discussion features proteinases, continues an outline functions both precursor mature polypeptides present picornaviral infection, concludes brief summary nonviral substrates cleaved by proteinases. Viral proteinases including L protein, 2A proteinase 3C have been discussed chapter. The aphthoviruses cardioviruses code for protein at N terminus polyproteins. cleavage activity from foot-and-mouth disease virus (FMDV), aphthovirus, has well characterized. carries out majority proteolytic processing polyprotein. evolution picornaviruses might dictate that P1 to PN substrate positions be identical or similar optimize polyprotein maximize generation proteins. In vitro synthesized RNAs containing large inframe deletions within region are self-replicating cultured cells, suggesting proteins required RNA replication located primarily P2 P3 (nonstructural) regions genome. Since utilize mechanism translation is cap independent, it advantageous inhibit nonessential cap-dependent cellular translation.