Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children.

摘要: We compared the clinical and demographic features of children with lower respiratory tract infection (LRI) caused by human metapneumovirus (HMPV) syncytial virus (RSV) influenza A sought to determine whether coinfection HMPV other viruses leads increased disease severity. Nasal wash specimens were prospectively obtained from 516 hospitalized for LRI during a 1-year period tested presence reverse transcription-polymerase chain reaction RSV direct immunofluorescence. was detected in 68 (13%) patients third most common viral pathogen; 16 HMPV-positive (24%) had (HMPVco). older than (17.6 ± 16.8 months versus 10.5 11.8 P = 0.02). associated wheezing hypoxemia at rate similar that higher A. Atelectasis more among (40%) (13% < 0.05 each). often diagnosis pneumonia asthma less bronchiolitis (P each) even when corrected age. Children HMPVco gastrointestinal symptoms but did not show severe picture. The pattern closely resembles yet differences age radiographic findings suggest pathogenesis may differ RSV. (authors)