Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells
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DOI: 10.1128/9781555817657.CH25
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摘要: Mycobacterium tuberculosis is an intracellular pathogen of mononuclear phagocytes and highly adapted to the human host. This chapter reviews advances in understanding molecular determinants that mediate interaction M. with host cells such as monocytes/ macrophages, epithelial cells, dendritic cell (DC). In this context, it also a family important regulators innate immune activation, toll-like receptor (TLR) family. The mannose caps wall LAM (ManLAM) have recently been shown be recognized by DC-SIGN on DC, lectin functions bacterial adhesion pattern recognition receptor. addition lipoarabinomannan (LAM)-mannose (MR) interaction, strains possess their own lectins, some which are specific for mannans may involved binding cells. Toll member related proteins fly defense against pathogens, most probably because they direct production antimicrobial peptides. cytoplasmic domain was found homologous mammalian interleukin-1 (IL-1) IL-18 receptors, suggesting similar receptors might encoded genome. Some TLR utilize coreceptors augment TLR-dependent responses and, cases, required function. Recently, several laboratories investigated roles TLR2 TLR4 mycobacterial infection.
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