Choroid plexus implants rescue Alzheimer’s disease-like pathologies by modulating amyloid-β degradation

作者: Marta Bolos , Desireé Antequera , Jesús Aldudo , Henrike Kristen , María Jesús Bullido

DOI: 10.1007/S00018-013-1529-4

关键词:

摘要: … Transplantation of CPEC in vivo reduced Aβ-like pathology in APP/PS1 transgenic mice, and resulted in significant behavioral recovery of memory. …

参考文章(45)
Han-Chang Huang, Zhao-Feng Jiang, Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease. Journal of Alzheimer's Disease. ,vol. 16, pp. 15- 27 ,(2009) , 10.3233/JAD-2009-0960
E DELANGE, Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Advanced Drug Delivery Reviews. ,vol. 56, pp. 1793- 1809 ,(2004) , 10.1016/J.ADDR.2004.07.009
Kenneth M. Lanzetta, Noriaki Yahata, Sebastian Pascarelle, Hsiao-Wen Chen, Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68 Nature. ,vol. 408, pp. 562- 564 ,(2000) , 10.1038/35046031
Jiraganya Bhongsatiern, Sumio Ohtsuki, Masanori Tachikawa, Satoko Hori, Tetsuya Terasaki, None, Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain Journal of Neurochemistry. ,vol. 92, pp. 1277- 1280 ,(2005) , 10.1111/J.1471-4159.2004.02941.X
K. G. Mawuenyega, W. Sigurdson, V. Ovod, L. Munsell, T. Kasten, J. C. Morris, K. E. Yarasheski, R. J. Bateman, Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease Science. ,vol. 330, pp. 1774- 1774 ,(2010) , 10.1126/SCIENCE.1197623
Dale Schenk, Robin Barbour, Whitney Dunn, Grace Gordon, Henry Grajeda, Teresa Guido, Kang Hu, Jiping Huang, Kelly Johnson-Wood, Karen Khan, Dora Kholodenko, Mike Lee, Zhenmei Liao, Ivan Lieberburg, Ruth Motter, Linda Mutter, Ferdie Soriano, George Shopp, Nicki Vasquez, Christopher Vandevert, Shannan Walker, Mark Wogulis, Ted Yednock, Dora Games, Peter Seubert, Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. ,vol. 400, pp. 173- 177 ,(1999) , 10.1038/22124
Laura Gasparini, Gunnar K Gouras, Rong Wang, Rachel S Gross, M Flint Beal, Paul Greengard, Huaxi Xu, None, Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling The Journal of Neuroscience. ,vol. 21, pp. 2561- 2570 ,(2001) , 10.1523/JNEUROSCI.21-08-02561.2001
Malcolm A Leissring, Wesley Farris, Alice Y Chang, Dominic M Walsh, Xining Wu, Xiaoyan Sun, Matthew P Frosch, Dennis J Selkoe, None, Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death Neuron. ,vol. 40, pp. 1087- 1093 ,(2003) , 10.1016/S0896-6273(03)00787-6
Janelle S. Crossgrove, Ellen L. Smith, Wei Zheng, Macromolecules involved in production and metabolism of beta-amyl oid at the brain barriers Brain Research. ,vol. 1138, pp. 187- 195 ,(2007) , 10.1016/J.BRAINRES.2006.12.022
Andrew K. Wise, James B. Fallon, Alison J. Neil, Lisa N. Pettingill, Marilyn S. Geaney, Stephen J. Skinner, Robert K. Shepherd, Combining Cell-Based Therapies and Neural Prostheses to Promote Neural Survival Neurotherapeutics. ,vol. 8, pp. 774- 787 ,(2011) , 10.1007/S13311-011-0070-0