Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain
作者： Jiraganya Bhongsatiern , Sumio Ohtsuki , Masanori Tachikawa , Satoko Hori , Tetsuya Terasaki
DOI: 10.1111/J.1471-4159.2004.02941.X
关键词:
摘要: ATP-binding cassette (ABC) transporter A4 is a member of the ABC subfamily A which has been reported to be exclusively expressed in retina. In contrast, previous report suggested possible relationship between ABCA4 and CNS function. The purpose present study was investigate localization mRNA protein rat brain. situ hybridization analysis revealed that localized lateral ventricles. RT-PCR detected isolated choroid plexus conditionally immortalized epithelial cells (TR-CSFB). Furthermore, also at about 250 kDa by western blot analysis, its apparent molecular size reduced N-glycosidase F treatment. These results suggest glycosylated cells. may play role function blood-cerebrospinal fluid barrier affect CSF conditions.
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sci-hub.se 参考文章(21)
Miwako Yamasaki, Keiko Yamada, Shigeki Furuya, Junya Mitoma, Yoshio Hirabayashi, Masahiko Watanabe, 3-Phosphoglycerate dehydrogenase, a key enzyme for L-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain The Journal of Neuroscience. ,vol. 21, pp. 7691- 7704 ,(2001) , 10.1523/JNEUROSCI.21-19-07691.2001
Takeo Kitazawa, Ken-ichi Hosoya, Masatomi Watanabe, Tadayuki Takashima, Sumio Ohtsuki, Hitomi Takanaga, Masatsugu Ueda, Nobuaki Yanai, Masuo Obinata, Tetsuya Terasaki, None, Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier. Pharmaceutical Research. ,vol. 18, pp. 16- 22 ,(2001) , 10.1023/A:1011014424212
A.H. Schinkel, S. Kemp, M. Dollé, G. Rudenko, E. Wagenaar, N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein Journal of Biological Chemistry. ,vol. 268, pp. 7474- 7481 ,(1993) , 10.1016/S0021-9258(18)53199-9
Rolf H. Zetterström, Eva Lindqvist, Alexander Mata De Urquiza, Andreas Tomac, Ulf Eriksson, Thomas Perlmann, Lars Olson, Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid. European Journal of Neuroscience. ,vol. 11, pp. 407- 416 ,(1999) , 10.1046/J.1460-9568.1999.00444.X
Malcolm Maden, Retinoid signalling in the development of the central nervous system Nature Reviews Neuroscience. ,vol. 3, pp. 843- 853 ,(2002) , 10.1038/NRN963
Miyuki Yamamoto, Peter McCaffery, Ursula C. Dräger, Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis Developmental Brain Research. ,vol. 93, pp. 182- 190 ,(1996) , 10.1016/0165-3806(96)00038-7
Rando Allikmets, Nanda Singh, Hui Sun, Noah F. Shroyer, Amy Hutchinson, Abirami Chidambaram, Bernard Gerrard, Lisa Baird, Dora Stauffer, Andy Peiffer, Amir Rattner, Philip Smallwood, Yixin Li, Kent L. Anderson, Richard Alan Lewis, Jeremy Nathans, Mark Leppert, Michael Dean, James R. Lupski, A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy Nature Genetics. ,vol. 15, pp. 236- 246 ,(1997) , 10.1038/NG0397-236
Hui Sun, Robert S. Molday, Jeremy Nathans, Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease Journal of Biological Chemistry. ,vol. 274, pp. 8269- 8281 ,(1999) , 10.1074/JBC.274.12.8269
Sassan M. Azarian, Gabriel H. Travis, The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR). FEBS Letters. ,vol. 409, pp. 247- 252 ,(1997) , 10.1016/S0014-5793(97)00517-6
Sumio Ohtsuki, Yuki Watanabe, Satoko Hori, Hiroya Suzuki, Jiraganya Bhongsatiern, Masachika Fujiyoshi, Mayu Kamoi, Naoko Kamiya, Hitomi Takanaga, Tetsuya Terasaki, None, mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells Biological & Pharmaceutical Bulletin. ,vol. 27, pp. 1437- 1440 ,(2004) , 10.1248/BPB.27.1437