The structural basis of the activation of Ras by Sos

作者: P. Ann Boriack-Sjodin , S. Mariana Margarit , Dafna Bar-Sagi , John Kuriyan

DOI: 10.1038/28548

关键词:

摘要: … and the associated magnesium ion, so that their binding is no longer favoured. Sos does … Cell-surface receptors that signal through tyrosine kinases activate Ras by stimulating the …

参考文章(45)
Edwin M. Westbrook, Istvan Naday, [17] Charge-coupled device-based area detectors. Methods in Enzymology. ,vol. 276, pp. 244- 268 ,(1997) , 10.1016/S0076-6879(97)76063-4
Scott Powers, Shayne Y. Huff, Channing J. Der, Char Chang Lai, Sei Yu Chen, Ras-15A protein shares highly similar dominant-negative biological properties with Ras-17N and forms a stable, guanine-nucleotide resistant complex with CDC25 exchange factor. Oncogene. ,vol. 9, pp. 2691- 2698 ,(1994)
AC Verrotti, JB Crechet, F Di Blasi, G Seidita, MG Mirisola, C Kavounis, V Nastopoulos, E Burderi, E De Vendittis, A Parmeggiani, O Fasano, RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP. The EMBO Journal. ,vol. 11, pp. 2855- 2862 ,(1992) , 10.1002/J.1460-2075.1992.TB05353.X
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
Jacqueline Cherfils, Julie Ménétrey, Magali Mathieu, Gérard Le Bras, Sylviane Robineau, Sophie Béraud-Dufour, Bruno Antonny, Pierre Chardin, Structure of the Sec7 domain of the Arf exchange factor ARNO Nature. ,vol. 392, pp. 101- 105 ,(1998) , 10.1038/32210
R D Mosteller, J Han, D Broek, Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors. Molecular and Cellular Biology. ,vol. 14, pp. 1104- 1112 ,(1994) , 10.1128/MCB.14.2.1104
R H Medema, A M de Vries-Smits, G C van der Zon, J A Maassen, J L Bos, Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Molecular and Cellular Biology. ,vol. 13, pp. 155- 162 ,(1993) , 10.1128/MCB.13.1.155
Louis Renault, Nicolas Nassar, Ingrid Vetter, Jörg Becker, Christian Klebe, Michel Roth, Alfred Wittinghofer, The 1.7 Å crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller Nature. ,vol. 392, pp. 97- 101 ,(1998) , 10.1038/32204