Dendritic spines: structure, dynamics and regulation.
作者： Heike Hering , Morgan Sheng
DOI: 10.1038/35104061
关键词:
摘要: Dendritic spines are tiny protrusions that receive excitatory synaptic input and compartmentalize postsynaptic responses. Heterogeneous in size shape, modifiable by activity experience, dendritic have long been thought to provide a morphological basis for plasticity. Although advanced imaging techniques highlighted the rapid regulated motility of living neurons, functional significance spine plasticity remains elusive. Recent insights into molecular mechanisms regulate morphogenesis offer potential ways manipulate vivo explore their physiological roles brain.
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