作者: Akila N. Viswanathan , Jackie Szymonifka , Clare M. Tempany-Afdhal , Desmond A. O’Farrell , Robert A. Cormack
DOI: 10.1016/J.BRACHY.2012.08.006
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摘要: Abstract Purpose To present outcome and toxicity results of the first real-time intraoperative MRI-guided interstitial approach to gynecologic cancer. Methods Materials From February 2004 December 2006, 25 patients with malignancies were enrolled treated in a prospective clinical trial brachytherapy. This was followed by confirmatory CT imaging scan. Statistical analyses included Kaplan–Meier estimates for overall relapse-free survival. Results MRI visualization needles during placement permitted accurate no inadvertent insertions. prevented unnecessary normal-tissue perforation as confirmed simulation. With mean followup 3.8 years (range, 2–6.8), 1-, 2-, 3-year survival rates 80%, 60% 43%, respectively; corresponding 79%, 65%, 59%, respectively. Actuarial acute any grade 0% at 0–14 days 80% (all 1) 14–90 days. Long-term (>180 days) actuarial 8% gastrointestinal, 4% bladder vaginal. Conclusions Real-time guidance insertion 3D-planning maximized opportunities tumor targeting sparing normal tissues. Although image requires additional anesthesia time, outcomes indicate potential successful reduction using 3D image-guided addition image-planned