A prospective trial of real-time magnetic resonance–guided catheter placement in interstitial gynecologic brachytherapy

作者: Akila N. Viswanathan , Jackie Szymonifka , Clare M. Tempany-Afdhal , Desmond A. O’Farrell , Robert A. Cormack

DOI: 10.1016/J.BRACHY.2012.08.006

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摘要: Abstract Purpose To present outcome and toxicity results of the first real-time intraoperative MRI-guided interstitial approach to gynecologic cancer. Methods Materials From February 2004 December 2006, 25 patients with malignancies were enrolled treated in a prospective clinical trial brachytherapy. This was followed by confirmatory CT imaging scan. Statistical analyses included Kaplan–Meier estimates for overall relapse-free survival. Results MRI visualization needles during placement permitted accurate no inadvertent insertions. prevented unnecessary normal-tissue perforation as confirmed simulation. With mean followup 3.8 years (range, 2–6.8), 1-, 2-, 3-year survival rates 80%, 60% 43%, respectively; corresponding 79%, 65%, 59%, respectively. Actuarial acute any grade 0% at 0–14 days 80% (all 1) 14–90 days. Long-term (>180 days) actuarial 8% gastrointestinal, 4% bladder vaginal. Conclusions Real-time guidance insertion 3D-planning maximized opportunities tumor targeting sparing normal tissues. Although image requires additional anesthesia time, outcomes indicate potential successful reduction using 3D image-guided addition image-planned

参考文章(24)
Akila N. Viswanathan, Jennifer Moughan, William Small, Charles Levenback, Revathy Iyer, Sharon Hymes, Adam P. Dicker, Brigitte Miller, Beth Erickson, David K. Gaffney, The quality of cervical cancer brachytherapy implantation and the impact on local recurrence and disease-free survival in radiation therapy oncology group prospective trials 0116 and 0128. International Journal of Gynecological Cancer. ,vol. 22, pp. 123- 131 ,(2012) , 10.1097/IGC.0B013E31823AE3C9
Akila N. Viswanathan, Beth E. Erickson, Jason Rownd, Image-Based Approaches to Interstitial Brachytherapy Springer, Berlin, Heidelberg. pp. 247- 259 ,(2011) , 10.1007/978-3-540-68958-4_24
Johannes C.A. Dimopoulos, Maximilian P. Schmid, Elena Fidarova, Daniel Berger, Christian Kirisits, Richard Pötter, Treatment of locally advanced vaginal cancer with radiochemotherapy and magnetic resonance image-guided adaptive brachytherapy: dose-volume parameters and first clinical results. International Journal of Radiation Oncology Biology Physics. ,vol. 82, pp. 1880- 1888 ,(2012) , 10.1016/J.IJROBP.2011.03.049
Beth Erickson, Katherine Albano, Mike Gillin, CT-guided interstitial implantation of gynecologic malignancies International Journal of Radiation Oncology Biology Physics. ,vol. 36, pp. 699- 709 ,(1996) , 10.1016/S0360-3016(96)00373-2
A.M.Nisar Syed, Ajmel A Puthawala, Nashwa Nazmy Abdelaziz, Mervat el-Naggar, Philip Disaia, Michael Berman, Krishnansu S Tewari, Anil Sharma, Adina Londrc, Supriya Juwadi, Joel M Cherlow, Steven Damore, Yi-Jen Chen, Long-term results of low-dose-rate interstitial-intracavitary brachytherapy in the treatment of carcinoma of the cervix. International Journal of Radiation Oncology Biology Physics. ,vol. 54, pp. 67- 78 ,(2002) , 10.1016/S0360-3016(02)02900-0
Gustavo S. Montana, A.L. Hanlon, T.J. Brickner, J.B. Owen, G.E. Hanks, C.C. Ling, R. Komaki, V.A. Marcial, G.M. Thomas, R. Lanciano, Carcinoma of the cervix: Patterns of care studies: Review of 1978, 1983, and 1988–1989 surveys International Journal of Radiation Oncology Biology Physics. ,vol. 32, pp. 1481- 1486 ,(1995) , 10.1016/0360-3016(95)00177-Z
Marisol De Brabandere, Amr Gaber Mousa, An Nulens, Ans Swinnen, Erik Van Limbergen, Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma Radiotherapy and Oncology. ,vol. 88, pp. 217- 226 ,(2008) , 10.1016/J.RADONC.2007.10.026
Akila N. Viswanathan, Beth A. Erickson, Three-Dimensional Imaging in Gynecologic Brachytherapy: A Survey of the American Brachytherapy Society International Journal of Radiation Oncology Biology Physics. ,vol. 76, pp. 104- 109 ,(2010) , 10.1016/J.IJROBP.2009.01.043
Akila N. Viswanathan, Robert Cormack, Bhupendra Rawal, Hang Lee, Increasing brachytherapy dose predicts survival for interstitial and tandem-based radiation for stage IIIB cervical cancer International Journal of Gynecological Cancer. ,vol. 19, pp. 1402- 1406 ,(2009) , 10.1111/IGC.0B013E3181B62E73
Avraham Eisbruch, Carolyn M Johnston, Mary K Martel, John M Robertson, Kevin R Reynolds, Lon H Marsh, James A Roberts, CUSTOMIZED GYNECOLOGIC INTERSTITIAL IMPLANTS: CT-BASED PLANNING, DOSE EVALUATION, AND OPTIMIZATION AIDED BY LAPAROTOMY International Journal of Radiation Oncology Biology Physics. ,vol. 40, pp. 1087- 1093 ,(1998) , 10.1016/S0360-3016(98)00010-8