Glycemic Variability: Should we and can we prevent it?

摘要: Diabetes is characterized by glycemic disorders that include both sustained chronic hyperglycemia and acute glucose fluctuations. There now cogent evidence for the deleterious effects of results in excessive protein glycation generation oxidative stress. The role variability from peaks to nadirs less documented, but there are many reasons think upward (postprandial) downward (interprandial) fluctuations around a mean value activate As consequence, it strongly suggested global antidiabetic strategy should be aimed at reducing minimum different components dysglycemia (i.e., A1C, fasting postprandial glucose, as well variability). All therapeutic agents act on excursions seem particular interest latter parameter instability). Particular attention paid such emerging glucagon-like peptide 1 agonists dipeptidyl peptidase (DPP)-IV inhibitors through incretin pathway.