Androgen receptor gene polymorphism and prostate cancer in Taiwan.

摘要: Background and Purpose: The length of polymorphic CAG trinucleotide repeats in the polyglutamine region androgen receptor (AR) gene has been suggested to be inversely correlated with transactivation function AR. An increase activity may associated prostate cancer, ethnic variations repeat contribute varying cancer risks different populations. This case-control study investigated potential role AR polymorphism risk Taiwanese. Methods: Sixty six pathologically-confirmed patients 104 controls were studied. was genotyped by a polymerase chain reaction (PCR)-based direct sequencing method. Logistic regression used determine relative number on risk. associations AR-CAG disease stage, pathologic grade, age at diagnosis assessed. first treated as continuous variable, then divided into short long groups (n＜23 vs n≥23) for categorical analysis. extreme distribution also analyzed these (n≤20 n≥26 n=21-25 n≥26). Results: mean similar: 23.2±3.0 (range, 15 31) 22.9±3.1 15to 31), respectively. No association found between stage (p=0.30), histological grade (p=0.49), or (p=0.51). After adjusting other covariates (age, body mass index, education level, smoking, alcohol status), not significantly [odds ratio (OR) =0.97, 95% confidence interval (95% CI) =0.72 1.31; p=0.84]. In analysis, men (n＜23) did have increased (OR=0.45, CI=0.29 1.05) compared those (n≥23). Non-significant differences when comparing group (n≤20) intermediate (n=21-25) (n≥26) [n≤20 n ≥26: OR =1.00, CI=0.34 3.00; n≥26: OR=0.82, CI=0.37to 1.81]. Conclusions: results this do support an important effect A large-scale is needed clarify genetic components Taiwanese population.